It has been documented that HIF-1α-BNIP3-mediated mitophagy mitigates renal fibrosis by inhibiting the activation of the NLRP3 inflammasome, and BNIP3-mediated mitophagy also exerts a protective effect on neuroinflammation by suppressing the assembly of the NLRP3 inflammasome (33, 34). The gene discussed is HIF1A; the disease is renal fibrosis.