Conversely, clusters #1 (tumor microenvironment), #3 (cells), #5 (nlrp3 inflammasome), #6 (atherosclerosis), #7 (rheumatoid arthritis), and #8 (allergic rhinitis) exhibit sustained research activity extending to the present, indicating their status as persistent areas of scientific investigation. This evidence concerns the gene NLRP3 and atherosclerosis.