SP-A genetic variants (particularly 6A2 and 1A3) seem more capable of attenuating the robust induction of cytokines observed in severe COVID-19 and SP-A gene variants are protective (albeit differentially) in response to SARS-CoV-2 infection by distinctively activating immune genes and signaling pathways (Figure 9). The gene discussed is SFTPA1; the disease is COVID-19.