In diffuse large B-cell lymphoma (DLBCL), the expression of TREM2 on M-MDSCs has been found to be associated with immunosuppressive functions, potentially by upregulating the expression of Arginase 1 (ARG1) to inhibit the proliferation of CD8+ T cells, thereby promoting tumor growth. This evidence concerns the gene CD8A and diffuse large B-cell lymphoma.