TREM2 and neurodegenerative disease: One example is VGL101 (NCT05677659), also known as iluzanebart, a fully human TREM2 monoclonal antibody agonist used to treat adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP), a rare and fatal neurodegenerative disease caused by mutations in the CSF1R gene.