As for renal cell carcinoma (RCC), research has shown that the expression level of TREM2 in RCC tumor tissues was abnormally elevated, and that TREM2 exerts a crucial oncogenic effect by modulating apoptosis-related proteins and the PTEN-PI3K/AKT signaling pathway (130). Here, TREM2 is linked to hereditary clear cell renal cell carcinoma.