Furthermore, in the context of ischemic stroke, the expression of perilipin-2 (Plin2) is upregulated, and the expression of ATP-binding cassette transporter A1 (ABCA1) is downregulated, leading to increased lipid droplet formation and impaired cholesterol clearance in TREM2-deficient microglia (79). Here, ABCA1 is linked to ischemic stroke.