In the unilateral ureteral obstruction (UUO) mouse model, TREM2 is highly expressed in DCs and exerts a protective role in chronic kidney disease (CKD) by regulating the production of NO to inhibit the differentiation of Th17 cells and the production of IL-17, thereby alleviating renal inflammation and fibrosis (36). The gene discussed is TREM2; the disease is chronic kidney disease.