The International Society on Thrombosis and Hemostasis (ISTH) score of 5 (overt disseminated intravascular coagulation) is corroborated by prolonged prothrombin time, severe hypofibrinogenemia, and thrombocytopenia, providing a clear diagnostic framework for this consumptive coagulopathy. The gene discussed is F2; the disease is Thrombocytopenia.