A prospective cohort study investigating the effects of C-reactive protein (CRP) levels and dyslipidemia on stroke reported that elevated CRP levels and dyslipidemia were associated with an increased stroke risk in men (33).Similarly, studies have indicated that serum CRP levels rise significantly 48–72 h post-admission in patients with HS, with the magnitude of elevation correlating with hematoma volume (34).As an inflammatory marker, CRP levels rise rapidly during stroke, likely in response to immune activation triggered by ischemic or hemorrhagic brain injury. This evidence concerns the gene CRP and histiocytic sarcoma.