This finding resonates with preclinical studies where curcumin reduced radiation-induced dermatitis in mice by modulating TGF-β pathways (Jagetia and Rajanikant, 2012) and a C. longa extract protected against 5-fluorouracil-induced oral mucositis in hamsters (Araújo et al., 2022). This evidence concerns the gene TGFB1 and dermatitis.