HIF1A and hepatocellular carcinoma: The results demonstrated that curcumol is involved in several key signaling pathways related to sorafenib-resistant HCC, including “Pathways in cancer”, “PI3K-Akt signaling pathway”, “HIF-1 signaling pathway”, “Ras signaling pathway”, “mTOR signaling pathway”, and “JAK-STAT signaling pathway” (Figures 3E, F).