The pathological biological function of APOE is closely linked to Aβ; in model mice, the knockout of the endogenous APOE gene alters the morphology of Aβ, and the APOEɛ4 allele slows down the hydrolysis of Aβ proteins, further accelerating the progression of AD (Raulin et al., 2022). The gene discussed is APOE; the disease is Alzheimer disease.