Our RNA-Seq analysis identified Platelet endothelial cell adhesion molecule-1 (PECAM1), type I collagen α2 chain (COL1A2), THBS2 (thrombospondin-2), and type III collagen α1 chain (COL3A1) as potential therapeutic targets in CRC, with each gene being closely associated with fibroblast activity. The gene discussed is COL3A1; the disease is colorectal carcinoma.