NLRP3 and type 2 diabetes mellitus: Studies have demonstrated that silencing NLRP3 can inhibit pyroptosis in H9c2 cardiomyocytes exposed to high-glucose conditions and ameliorate cardiac pyroptosis, inflammation, and fibrosis in Type 2 diabetes mellitus (T2DM) rats (Luo et al., 2014; Yang et al., 2018).