Cas-1 cut leads to the cleavage of downstream cytokines pro-Interleukin-1 beta (pro-IL-1β) and pro-Interleukin-18 (pro-IL-18) into their mature forms IL-1β, IL-18, thereby inducing cardiomyocyte damage and subsequently resulting in myocardial hypertrophy, fibrosis, and impaired cardiac function (Denes et al., 2012; Vande Walle and Lamkanfi, 2020). The gene discussed is IL18; the disease is cardiac hypertrophy.