Most tumors in the gastrointestinal tract with EWSR1/FUS and CREB family fusions (EWSR1/FUS::CREB fusion) are reportedly clear cell sarcoma-like tumors of the gastrointestinal tract (CCSLGT).2,3) Here, we report our experience with a gastric epithelioid mesenchymal tumor with an EWSR1::CREM fusion that was distinct from established entities. This evidence concerns the gene CREB1 and mesenchymal cell neoplasm.