After adjustment for patients' age, gender and BMI, only ALT and ALP were the significant predictors for acute cholecystitis where higher ALT levels were associated with 21% more likelihood of acute cholecystitis (AOR = 1.21; 95% CI: 1.01–1.98) and higher level of ALP was associated with 24% more likelihood for acute cholecystitis (AOR = 1.24; 95% CI: 1.11–1.99). The gene discussed is GPT; the disease is Cholecystitis, Acute.