Studies suggest that the pathways and the impact of MEG3 downregulation in pRCC may differ slightly due to the histological and molecular differences between ccRCC and pRCC (118).Thus, while both ccRCC and pRCC show a trend of reduced MEG3 expression, the details, extent, and implications of this downregulation appear to vary, reflecting the distinct biological behaviors of these RCC subtypes. This evidence concerns the gene MEG3 and renal cell adenocarcinoma.