NOX4 and neoplasm: While EGFR mutation may influence FDG uptake via the NADPH oxidase 4 (NOX4)/reactive oxygen species (ROS)/glucose transporter protein 1 (GLUT1) axis (13), the predictive value of 18F-FDG PET/CT metabolic parameters - such as the maximum standard uptake value (SUVmax), mean standard uptake value (SUVmean), total lesion glycolysis (TLG) and metabolic tumor volume (MTV) - remains controversial in the context of EGFR mutation status (14).