The interplay of the tumor-derived molecules like immune checkpoint ligands (PD-L1 and PD-L2), chemokines (CXCL9, CXCL10, and CXCL12), along with cytokines (TGF-β and IL-10), creates a complex immunosuppressive environment in EwS. The gene discussed is CXCL12; the disease is neoplasm.