The removal of NK cells negates the tumor-suppressive effects of ubiquitin-specific protease 6 (USP6) in EwS xenograft models, highlighting their significance in tumor immunity (Table 1)[39]. USP6 acts as a tumor suppressor in EwS and is the first recognized cell-intrinsic factor shown to influence the immune TME in this disease [39]. Here, USP6 is linked to neoplasm.