In addition to moderate to strong SDHB staining, we observed an absence of immunostaining for 5hmC in all 3 tumors, indicating a hypermethylated tumor profile (Fig. 4), which is characteristic of tumors associated with SDHx defects and paragangliomas in patients harboring pathogenic variants in SLC25A11 [18]. This evidence concerns the gene SDHB and paraganglioma.