In addition, the TLR4 signaling pathway promotes the secretion of IL-12 (88) and induces the differentiation of naive CD4+ T cells towards the Th1 lineage through the STAT4 signaling pathway (89), which may lead to Th1/Th2 imbalance, causing abnormal immune responses and subsequently affecting the function of the nervous system, related to the occurrence and development of schizophrenia (90). This evidence concerns the gene STAT4 and schizophrenia.