In the valproic acid‐induced autism model, treatment of STX209 (a GABABR2 agonist) ameliorated autism‐like behaviors in the locomotion activity, sociability and preference, novelty recognition and marble‐burying via improving the spine density and GABABR2 expression in the hippocampal DG /CA1 [174] and offspring of mice, prenatal baclofen administration significantly increased density of dendritic spines in the hippocampus and medial PFC, correcting the core autism‐like behaviors in F2 mice [175]. Here, GABBR2 is linked to autism.