In animal models of AD, baclofen can improve the spatial memory and learning ability of AD rats [166], activation of GABABR reduces the oxidative stress injury (MDA, SOD, and GSH‐Px) [167], and suppresses the neuronal apoptosis, inhibiting p‐tau and Aβ formation by the PI3K/AKT signaling pathway [166]. This evidence concerns the gene SOD1 and Alzheimer disease.