Analysis of the area under the ROC curve (95% confidence interval) showed that both IFN-α2 concentration (area under the curve = 0.771) and IFN-I score (area under the curve = 0.917) robustly discriminate type I interferonopathies and IFN-I–related autoimmune diseases from others with an advantage of the transcriptomic approach (P < .001) (Fig 2, B). This evidence concerns the gene IFNA2 and autoimmune disease.