STAT3 and Hypertension: Furthermore, pravastatin can also prevent the elevated oxidative stress induced by hypertension in pregnancy.(22) Complementarily, it inhibited the interleukin-6/protein signal transducer and activator of transcription 3 (IL-6/STAT3) signaling pathway, alleviating oxidative stress and reducing placental trophoblast cell apoptosis in rats with PE.(21)