Previous studies reported a strong GRPR staining in cervical cancer samples by immunohistochemical analysis and raised the hypothesis that GRPR expression could serve as a valuable diagnostic marker for early detection of this type of tumor.(15,21) However, there is limited available data exploring GRPR expression in cervical neoplasia and none of the previous studies evaluated the correlation between HPV infection and GRPR in this scenario. The gene discussed is GRPR; the disease is cervical carcinoma.