High GRPR expression has been observed in cervical tumors, while its levels are usually low in healthy tissues.(16,21,22) Previous studies have shown that GRPR immunostaining demonstrated high sensitivity, specificity, and accuracy in detecting cervical invasive cancer.(21) However, there is a lack of data exploring the possible correlation between HPV infection and GRPR in cervical cancer. This evidence concerns the gene GRPR and uterine cervix neoplasm.