Another condition currently under the spotlight for gene supplementation approaches is autosomal recessive achromatopsia (ACHM), with both animal studies and several human phase I/II trials underway for ACHM related to CNGA3 and CNGB3 variants (NCT03758404 and NCT03001310, Farahbakhsh et al., NCT02935517, NCT02599922, NCT0261058212) (3–12). This evidence concerns the gene CNGA3 and achromatopsia.