In addition, studies have shown that miR-21-5p promotes tumor progression by regulating the ubiquitination of SIRT7 (Hu et al., 2023); while miR-148b-3p, miR-770 and PYCR1 protein target SIRT7 to inhibit its expression or transcription (Sun et al., 2018; Zheng et al., 2023; Li et al., 2024a). This evidence concerns the gene SIRT7 and neoplasm.