FOXO4 and pulmonary fibrosis: Choudhury found that SIRT7 regulates glutamine metabolism through the TGF-β/SIRT7/FOXO4 axis, promotes the deacetylation of FOXO4, thereby inhibiting the expression of GLS1, and thus controls the progression of pulmonary fibrosis (Choudhury et al., 2020, p. 1).