Adeno-associated virus delivery of SIRT6 can significantly reduce bleomycin-induced alveolar epithelial cell damage and lung fibrosis Zhang et al. found that restoring SIRT3 expression enhances its activation of HIF-1α, which in turn suppresses TGF-β1 levels, thereby improving EMT and pulmonary fibrosis (Zhang et al., 2019a). Here, SIRT6 is linked to pulmonary fibrosis.