Studies of a bleomycin-induced PF model showed that mice lacking NLRP3, ASC, or caspase-1 had reduced IL-1β secretion from the lungs, accompanied by a decrease in the degree of inflammation and fibrosis (Stout-Delgado et al., 2016; Wei et al., 2023). The gene discussed is CASP1; the disease is pemphigus foliaceus.