For example, Ji-Hong et al. found that baicalein can inhibit the downregulation of Sirt3 expression induced by bleomycin in the lung, thereby inhibiting the TGF-β1/Smad signaling pathway and lung fibrosis, providing a novel experimental basis for the treatment of IPF (Ji-Hong et al., 2023). This evidence concerns the gene SIRT3 and idiopathic pulmonary fibrosis.