IL18 and Menkes disease: With extensive studies, cytokine production in response to MDV infection and their potential immune functions against MD have been described including IL4 (Heidari et al., 2008), IL6 (Kaiser et al., 2003; Abdul-Careem et al., 2007), IL10 (Lian et al., 2012), IL18 (Smith et al., 2011; Kaiser et al., 2003; Abdul-Careem et al., 2007), and IFN-© (Xing and Schat, 2000; Kano et al., 2009b).