For instance, NCOA3 upregulation leads to the suppression of inflammatory responses in postoperative ileus while aggravation of inflammation in rheumatoid arthritis.24 Through a series of experiments, our results showed that IGF2BP2 upregulation increased the m6A levels of NCOA3 as well as the mRNA level and mRNA half-life period of NCOA3, suggesting that IGF2BP2 may recognize and bind to the m6A site of NCOA3 and then increase the mRNA stability of NCOA3. Here, IGF2BP2 is linked to rheumatoid arthritis.