METTL3 and oral cavity squamous cell carcinoma: By the way, METTL3 stimulated miR-222-3p expression by mediating the m6A modification of pri-miR-222-3p.27 IGF2BP2 activation reversed the METTL3 knockdown-mediated inhibition of malignancy in oral squamous cell carcinoma.28 There may be interactions among METTL3, miR-222-3p, and IGF2BP2, which should be illustrated in future work.