The GSEA results revealed that there was a significant enrichment of pathways that included TNF‐α signaling through NFκB, KRAS signaling, hypoxia, IFN‐α and IFN‐γ responses, apoptosis, UV radiation response, inflammatory responses, p53 responses, estrogen responses, signaling through IL‐2/STAT5, and adipogenesis within the orthotopic tumor dataset in comparison to the in vitro cell culture dataset (Fig. 3A and Fig. S5). Here, TNF is linked to neoplasm.