FN1 and neoplasm: Interestingly, it appeared that FN1 is more highly upregulated in areas with lower CA9 expression (Fig. S9) and areas with higher FN1 expression were also associated with an increased expression of fibroblast markers (Fig. S11), which may be a result of the presence of tumor cells that adopt a more mesenchymal phenotype as well as fibroblasts [57, 73].