EZH2 and plasma cell myeloma: This is in line with previous studies, where we and others showed that multiple epiplayers, including BET proteins, EZH2, G9a and HDACs, support high c-MYC levels in MM cells by enhancing its transcription and targeting these epiplayers resulted in a concomitant reduction in MYC levels and potent anti-myeloma activity [52, 56, 57].