Moreover, the total macrophages (Mφ; F4/80+), M1 phenotypical Mφ (F4/80+CD86+) and M2 phenotypical Mφ (F4/80+CD206+) were all greatly increased in tumour tissues regardless of the treatment received when compared with PBS, but the OMVs plus NIR treatment triggered the greatest changes (Figure 4F, G). The gene discussed is MRC1; the disease is neoplasm.