2022). Treatment with IR700@Nb289‐OMVs plus NIR increased significantly Iba1 expression in macrophages, whereas Nb289‐OMVs and IR700@Nb289‐OMVs administration just induced a slight but significant Iba1 upregulation in macrophages as compared with the control (Figure 4H, I), suggesting that tumour‐targeting OMVs can recruit and activate macrophages of the TME and that addition of IR700 can further boost this effect upon irradiation. The gene discussed is AIF1; the disease is neoplasm.