CD86 and neoplasm: Moreover, the total macrophages (Mφ; F4/80+), M1 phenotypical Mφ (F4/80+CD86+) and M2 phenotypical Mφ (F4/80+CD206+) were all greatly increased in tumour tissues regardless of the treatment received when compared with PBS, but the OMVs plus NIR treatment triggered the greatest changes (Figure 4F, G).