To address whether IR700@Nb289‐OMVs could transactivate the cGAS‐STING pathway in TME macrophages through cancer cell debris produced by NIR irradiation‐induced ICD, primary macrophages were treated with supernatants collected from Colon26 cells treated with NIR irradiation alone, IR700@Nb289‐OMVs alone and OMVs plus NIR. This evidence concerns the gene CGAS and cancer.