CTSG and plague: Moreover, we observed an enrichment for 10 proteins with direct antimicrobial activity (e.g. MPO, CTSG, DEFA1B), which also represented the most disparately packaged proteins between Yp and T3E EVs (Figure 5e), suggesting that the Y. pestis T3SS actively inhibits the packaging of antimicrobials that could significantly impact hPMN responses during plague.