KEGG and HALLMARK enrichment analyses of neoadjuvant sequencing data from our center indicated that low LHPP expression was associated with the enrichment of anti-tumor immune response pathways, including the PI3K-AKT-mTOR, JAK-STAT, and WNT-β-catenin signaling pathways (Fig. 3K, L). The gene discussed is AKT1; the disease is neoplasm.