Accordingly, the E3L.CETP mice, a unique, translational murine model of humanised dyslipidaemia [18, 22, 23] when fed a chow diet, displayed an accelerated age-dependent progression of the endothelial dysfunction, preceding atherosclerotic plaque development that might mimic the age-dependent development of the vascular dysfunction trajectory over the life course in humans with mild dyslipidaemia. This evidence concerns the gene CETP and endothelial dysfunction.