CETP and hyperlipidemia: Although non-targeted proteomics as well as multidirectional analysis of the proteome of the aorta did also not uncover any specific biomarker, it was demonstrated based on these analyses that ageing rather than hyperlipidemia had a dominant impact on the outcome of the proteome analysis in both aorta and plasma samples in old E3L.CETP mice and C57BL/6J mice.