Yet, it must be emphasised again that these lesions that were found in 16–18-month-old E3L.CETP female mice fed chow diet represent quite an early stage of atherosclerosis development, incomparable with the atherosclerotic plaques found for example in ApoE/LDLR−/− mice fed chow diet [30] or E3L.CETP mice fed Western diet [19, 21]. This evidence concerns the gene LDLR and atherosclerosis.