There were also only one upregulated (heat shock protein family A—Hspa5) and only one downregulated (apolipoprotein A1—Apoa1) hyperlipidaemia-dependent DEPs independent of strain and sex of mice (Fig. S15C–D) with a similar pattern of changes in 8- and 28-week-old mice. This evidence concerns the gene APOA1 and hyperlipidemia.