In contrast to the aortic proteome, the plasma proteome revealed only one upregulated (immunoglobulin heavy constant gamma 2) and one downregulated (periostin) DEPs independent of strain and sex of mice, suggesting that some of age-related DEPs in plasma could reflect difference in the level of endothelial dysfunction development in male vs female E3L.CETP mice. The gene discussed is POSTN; the disease is endothelial dysfunction.