CETP and endothelial dysfunction: Importantly, the level of age-dependent endothelial dysfunction development, expressed as a delta of changes between 40-week-old and 8-week-old mice, was higher in E3L.CETP male mice than E3L.CETP female mice (− 28.37 vs − 17.57%, respectively; Fig. 1C), which eventually led to more severe endothelial dysfunction development in 40-week-old male than 40-week-old female E3L.CETP mice (− 21.3% in E3L.CETP male mice vs − 9.5% in E3L.CETP female mice, Fig. 1A–B).