GPX1 and endothelial dysfunction: However, some of them, i.e. upregulated DEPs related to inflammation (serum amyloid A1, haptoglobin, orosomucoid 2) and downregulation of DEPs (biliverdin reductase B, glutathione peroxidase 1, haemoglobin subunit alpha) related to oxidative stress, were identified in E3L.CETP vs C57BL/6J male mice and these processes could have contributed to increased oxidative stress [82–84], and more pronounced endothelial dysfunction in E3L.CETP vs C57BL/6J male mice.