There are various murine models of hyperlipidaemia and atherosclerosis including apolipoprotein E-deficient (ApoE−/−) and low-density lipoprotein receptor-deficient (LDLR−/−) or double knockout (ApoE/LDLR−/−) mice with rodent-like lipid profile and only a few models with humanised profile of lipid profile. The gene discussed is APOE; the disease is hyperlipidemia.