The regulation of metabolic pathways (contrary to DEPs involved in ageing in E3L.CETP mice—upregulation of DEPs) as well as inflammation were also the dominant processes, in which hyperlipidaemia-dependent (E3L.CETP vs C57BL/6J mice) DEPs were involved, in plasma of 8-week-old male mice. The gene discussed is CETP; the disease is hyperlipidemia.