Interestingly, we identified that early resilience in young female E3L.CETP mice to develop impaired vascular vasodilator function was associated with a switch from NO-dependent to H2O2-dependent vasodilation, blunted systemic proteomic response in plasma and then slower age-dependent deterioration of endothelial dysfunction in female versus male E3L.CETP mice. Here, CETP is linked to endothelial dysfunction.