TNF and brain neoplasm: KEGG pathway analysis on the highest-ranked ZIKV-infected brain tumour DEGs at 24 hpi identified ten significantly enriched terms that are predominantly involved in pathogen-host interaction (“Viral protein interaction with cytokine and cytokine receptor”, “Toll-like receptor signalling pathway”, “Influenza A” and “Amoebiasis”), immune response (“Cytokine-cytokine receptor interaction”, “TNF signalling pathway”, “NF-kappa B signalling pathway” and “IL-17 signalling pathway”) and cell death (“Apoptosis”) (Fig. 3D).