Data mining publicly available ZIKV-infected glioma and neuroblastoma RNA-Seq datasets, we observe that TNFRSF9 and one of its adaptors (TRAF1) are significantly upregulated in all cases, TNFSF9 is significantly upregulated in three instances, and TNF-alpha is significantly upregulated in all four brain tumour datasets (Fig. 4B). Here, TNF is linked to central nervous system cancer.