TNF and medulloblastoma: All immune cells express receptors for TNF-alpha (TNFRSF1A and TNFRSF1B) and IFN alpha (IFNAR1 and IFNAR2) and are enriched for these pathways, indicating that all these immune cell types are primed to respond to secreted TNF-alpha and IFN alpha in the medulloblastoma TME (Figs. 6B–D).