The pathological score of H&E was reduced in the si-Zbp1-AP group compared with the AP group, while the expression of serum amylase, lipase, and the inflammatory factor TNFα were improved (Fig. 4C); IHC of pancreatic tissues also showed that the level of inflammation, as well as the degree of inflammatory cell infiltration in the pancreas, were reduced to some extent (Fig. 4D). This evidence concerns the gene ZBP1 and alkaline phosphatase measurement.