TNF and alkaline phosphatase measurement: The pathological score of H&E was reduced in the si-Zbp1-AP group compared with the AP group, while the expression of serum amylase, lipase, and the inflammatory factor TNFα were improved (Fig. 4C); IHC of pancreatic tissues also showed that the level of inflammation, as well as the degree of inflammatory cell infiltration in the pancreas, were reduced to some extent (Fig. 4D).