Given that a recent investigation has suggested the link between the activation of SREBP1/SCD1 and ferroptosis inhibition in synovial fibroblasts cells [24], we hypothesized that C12ORF49 could inhibit ferroptosis and promote HCC growth by activating SREBP1/SCD1-mediated lipogenesis. This evidence concerns the gene SPRING1 and hepatocellular carcinoma.