SPRING1 and cancer: Considering the established role of Acyl-CoA thioesterases 9 (C12ORF49) as a pivotal regulatory element of SREBPs [20], which are essential transcriptional factors regulating the enzymes involved in de novo lipogenesis [18], which plays important roles in tumorigenesis and cancer development [18], the influences of C12ORF49 knockdown or overexpression on SREBPs and lipid metabolism were explored.