SPRING1 and hepatocellular carcinoma: In agreement, the enforced expression of either SREBP1 or SCD1 significantly mitigated the suppressive effects of C12ORF49 silencing on HCC cell viability and colony formation, whereas reduction of either SREBP1c or SCD1 clearly diminished the promotive effects of C12ORF49 upregulation on HCC growth in SNU-354 and SNU-739 cells (Fig. 7D, E).