However, Chong Huat Siar reported that although mesenchymal markers such as a-SMA, osteonectin, and N-cadherin are expressed, AM tumor cells largely retain their epithelial morphology, indicating the presence of intermediate hybrid phenotypes with both epithelial and mesenchymal characteristics.48 Our study is the first to definitively establish the presence of a p-EMT state in AM. The gene discussed is SPARC; the disease is neoplasm.