HMGB1 and fatty liver disease: The apoptotic-related speckled protein-deficient (ASC−/−) mice intestinal microbiota is dysfunctional after being fed with HFD, the expression of high-mobility group box 1 in dysfunctional microorganism-derived BEVs is significantly increased, and high-mobility group box 1 is transported to hepatocytes by BEVs, which may be the key factor for inducing hepatic steatosis (Chen et al., 2019) (Fig. 2).