DNMT3A and acute myeloid leukemia: Histological examination of BM, spleen, liver, heart and lungs showed a higher incidence of myeloproliferative neoplasm (MPN)/AML in Dnmt3aR882H/+ mice (37%, 13 of 35 Fig. 1i,j), reflecting the higher risk of progression to AML of DNMT3A-R882 compared to other DNMT3A mutations1.