The widely recognised ND associated protein aggregates include amyloid-β and tau in Alzheimer’s disease [2], [3], α-synuclein in Parkinson’s disease [4], [5], [6], and TDP-43 in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTD) [7], [8]. The gene discussed is TARDBP; the disease is Alzheimer disease.