TPD-43 protein aggregates are found in several neurodegenerative diseases, such ALS, FTD and AD [9], [51], [52] and the presence of TDP-43 aggregates is associated with cytotoxicity both in mouse and cell models [22], [25], [53], [54], [55], [56], [57]. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.