Macrophages phagocytose NETs via macropinocytosis/lysosomal pathways, exhibiting enhanced efficiency through DNase pretreatment and pro-inflammatory polarization (LPS+IFN-γ) [27,28], whereas dysregulated NETs degradation may trigger inflammation, autoimmunity, and tumor progression [25,27,28,33]. The gene discussed is IFNG; the disease is neoplasm.