SFN exhibits epigenetic regulation in various cancers by inducing DNA methylation changes of cell cycle regulators such as p21 and cyclin D2, TSGs, namely RARβ2, CDH1, DAPK1, PTEN, and GSTP1, and pro-apoptotic BAX, and further decreases expression levels of DNMTs leading to cell cycle arrest and apoptosis. Here, CDKN1A is linked to cancer.