AKT1 and acute lymphoblastic leukemia: We initially investigated the effect of incubation with PI3K/mTOR/Akt pathway inhibitors [AZD5363 (Akt), GDC0941 (pan PI3K), BEZ235 (pan PI3K+mTOR), and rapamycin (mTOR)] on CD21 expression across six T-ALL cell lines.