In this study, Plasma cells, CD8 T cells, memory-activated CD4 T cells, and follicular helper T cells were positively correlated with MMP9, CXCL10, and IL15 and negatively correlated with FOXO3, and these immune cells were aggregated in the synovial membrane of RA. The gene discussed is CXCL10; the disease is rheumatoid arthritis.