ERBB2 and breast cancer: For example, the ethanol extract (EEAC) inhibited the growth of A549 lung cancer cells, with an approximate IC50 of 170 μg/mL after 24 h of treatment, and migration via suppression of cav-1 expression and activation of p-AMPK, p21, and p27, and EEAC also suppresses ovarian carcinoma (SKOV-3) cell proliferation through HER-2/neu pathway inhibition (IC50 = 196 μg/mL) and demonstrates cytotoxic effects on breast cancer cells (MDA-MB-231: IC50 = 136 μg/mL; MCF-7: IC50 = 316 μg/mL) [78,99,100].