For cardiac arrhythmias (n = 143 cases), significant associations were observed for CYP27B1 rs4646536 under the genotypic (p = 0.009), recessive (p = 0.002), and allelic (p = 0.047) models, as well as for CYP27B1 rs3782130 under the genotypic (p = 0.014) and recessive (p = 0.004) models. This evidence concerns the gene CYP27B1 and chronic obstructive pulmonary disease.