CYP2R1 and chronic obstructive pulmonary disease: However, despite these limitations, our results remain robust after Bonferroni correction, confirming associations between CYP2R1 rs10741657 and CYP27B1 rs3782130 with general CVD risk, as well as CYP27B1 rs3782130 and CYP27B1 rs4646536 with cardiac arrhythmias.