Specifically, tumor tissues of Breast Invasive Carcinoma (BRCA), Colon Adenocarcinoma (COAD), Kidney Chromophobe (KICH), Kidney Renal Papillary Cell Carcinoma (KIRP), Lung Adenocarcinoma (LUAD), Lung Squamous Cell Carcinoma (LUSC), Prostate Adenocarcinoma (PRAD), Uterine Corpus Endometrial Carcinoma (UCEC) (p‐value < 0.001), and Bladder Urothelial Carcinoma (BLCA) (p‐value < 0.01), as well as Rectum Adenocarcinoma (READ) (p‐value < 0.05), displayed a significant downregulation in NLRP1 expression. This evidence concerns the gene NLRP1 and colon adenocarcinoma.