When utilizing the DNMIVD database to explore the methylation pattern of the NLRP1 gene's promoter across 22 distinct cancer types, we determined significant hypomethylation in the promoter region of the NLRP1 gene in ESCA (Beta difference = −0.219818 and adjusted p‐value = 0.000117) and PAAD (Beta difference = −0.202757 and adjusted p‐value = 0.003035) (Data S5). The gene discussed is NLRP1; the disease is cancer.