Through GSCA, a significant correlation was observed between NLRP1 downregulation and decreased OS in Adrenocortical Carcinoma (ACC) (p = 0.0013, HR = 0.28), HNSC (p = 0.031, HR = 0.74), KICH (p = 0.032, HR = 0.14), LUAD (p = 0.0066, HR = 0.66), PCPG (p = 0.024, HR = 0.12), Sarcoma (SARC) (p = 0.012, HR = 0.60), and SKCM (p = 0.00041, HR = 0.62). This evidence concerns the gene NLRP1 and adrenal cortex carcinoma.