Unlike other subtypes of LGMD that have less genotypic variability due to the prevalence of common founder mutations (i.e., LGMDR9) [7] or a paucity of pathogenic variants, such as LGMDD1, LGMDR1 has the greatest number of singleton pathogenic variants, leading to the question of whether or not this results in increased phenotypic variability. The gene discussed is CAPN3; the disease is limb-girdle muscular dystrophy.