NR4A1 and neoplasm: The primary treatment for early breast cancer is surgery followed by a single or a combination of adjuvant therapies including radiotherapy, chemotherapy, endocrine therapy, and targeted therapy.1 While treatment regimens are tailored based on tumour-node-metastasis staging, hormone receptor status and expression of other targetable receptors, mastectomy and breast conserving surgery (BCS) are the two main surgical options for the primary tumour.2