UB efficiently alleviated depression‐related behaviors, accompanied by suppressed microglia activation, neuroinflammation, changes of classic activation (M1)/alternative activation (M2) polarization and recovered sirtuin‐1 (SIRT1) and forkhead box protein O1 (FOXO1) expression in the hippocampus. The gene discussed is SIRT1; the disease is depressive symptom measurement.