Using AutoDock software, molecular docking were performed between the key hypothyroidism targets (TNF, IL6, IL1B, BCL2, PTSG2, and TP53) and the key constituents of QUF6 (quercetin, beta-sitosterol, kaempferol, 7-ketocholesterol, and rehmapicrogenin). This evidence concerns the gene TP53 and hypothyroidism.